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Home >Pharmaceutical > 3-Chloromethyl-benzotrifluoride
- Chemical Name: 3-Chloromethyl-benzotrifluoride
- CAS No.: 705-29-3
Cost-effective and customizable 3-Chloromethyl-benzotrifluoride 705-29-3 in stock
- Molecular Formula: C8H6ClF3
- Molecular Weight: 194.584
- Appearance/Colour: colorless to light yellow liquid
- Melting Point: 32-36 °C
- Refractive Index: n20/D 1.464(lit.)
- Boiling Point: 179.1 °C at 760 mmHg
- Flash Point: 48.9 °C
- PSA： 0.00000
- Density: 1.291 g/cm3
- LogP: 3.44420
705-29-3 Relevant articles
Method for synthesizing m-trifluoromethyl benzyl chloride through continuous flow
-
Paragraph 0044-0107, (2021/08/06)
The invention provides a method for synt...
Synthesis method of 1-phenyl-3-(3-trifluoromethylphenyl)-2-acetone
-
Paragraph 0005; 0010; 0011-0013, (2021/11/21)
The invention belongs to the technical f...
Preparation method of 3-trifluoromethylphenylacetonitrile
-
Paragraph 0007; 0033; 0036, (2017/08/27)
The invention discloses a preparation me...
Continuous-Flow Multistep Synthesis of Cinnarizine, Cyclizine, and a Buclizine Derivative from Bulk Alcohols
Borukhova, Svetlana,Nol, Timothy,Hessel, Volker
, p. 67 - 74 (2016/01/16)
Cinnarizine, cyclizine, buclizine, and m...
705-29-3 Process route
-
-
110-88-3
1,3,5-Trioxan
-
-
98-08-8
α,α,α-trifluorotoluene
-
-
705-29-3
3-Trifluoromethylbenzyl chloride
| Conditions | Yield |
|---|---|
|
With
chlorosulfonic acid; sulfuric acid; cetyltrimethylammonim bromide;
at 50 ℃;
for 0.05h;
|
85.6%
|
|
1,3,5-Trioxan;
With
thionyl chloride; sulfuric acid;
at -5 - 5 ℃;
for 0.5h;
α,α,α-trifluorotoluene;
With
iron(III) chloride;
at 0 - 5 ℃;
for 1h;
|
80%
|
-
-
98-08-8
α,α,α-trifluorotoluene
-
-
705-29-3
3-Trifluoromethylbenzyl chloride
| Conditions | Yield |
|---|---|
|
With
chlorosulfonic acid; sulfuric acid;
In
water;
at 20 - 30 ℃;
for 15h;
Large scale;
|
373 kg
|
705-29-3 Upstream products
-
349-75-7
3-(trifluoromethyl)benzyl alcohol
-
454-89-7
3-Trifluoromethylbenzaldehyde
-
454-92-2
3-(trifluoromethyl)benzoic acid
-
110-88-3
1,3,5-Trioxan
705-29-3 Downstream products
-
458-07-1
(3-(trifluoromethyl)benzyl)trimethylsilane
-
349-75-7
3-(trifluoromethyl)benzyl alcohol
-
21172-36-1
1-(but-3-en-1-yl)-3-(trifluoromethyl)benzene
-
800-67-9
1-{(2-[3-trifluoromethyl)phenyl]-1-phenylvinyl}benzene