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- Chemical Name: 4-BROMOBENZHYDRAZIDE
- CAS No.: 5933-32-4
High Quality Chinese Manufacturer supply 5933-32-4 4-BROMOBENZHYDRAZIDE
- Molecular Formula: C7H7BrN2O
- Molecular Weight: 215.049
- Appearance/Colour: Light beige powder
- Vapor Pressure: 1.34E-05mmHg at 25°C
- Melting Point: 167-169°C
- Refractive Index: 1.615
- Boiling Point: 353.2 °C at 760 mmHg
- PKA: 12.09±0.10(Predicted)
- Flash Point: 167.4 °C
- PSA： 55.12000
- Density: 1.615 g/cm3
- LogP: 2.14380
4-BROMOBENZHYDRAZIDE(Cas 5933-32-4) Usage
InChI:InChI=1/C7H7BrN2O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,9H2,(H,10,11)
5933-32-4 Relevant articles
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Najare, Mahesh S.,Patil, Mallikarjun K.,Garbhagudi, Manjunatha,Yaseen, Mohammed,Inamdar, Sanjeev R.,Khazi, Imtiyaz Ahmed M.
, (2021/02/06)
This paper primarily deals with the desi...
Design, synthesis, in vitro and in vivo evaluation against MRSA and molecular docking studies of novel pleuromutilin derivatives bearing 1, 3, 4-oxadiazole linker
Liu, Jie,Zhang, Guang-Yu,Zhang, Zhe,Li, Bo,Chai, Fei,Wang, Qi,Zhou, Zi-Dan,Xu, Ling-Ling,Wang, Shou-Kai,Jin, Zhen,Tang, You-Zhi
, (2021/05/17)
A class of pleuromutilin derivatives con...
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, p. 1739 - 1749 (2021/09/03)
We have prepared Schiff base functionali...
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The 2019 coronavirus disease (COVID-19) ...
5933-32-4 Process route
-
-
586-76-5
4-Bromobenzoic acid
-
-
5933-32-4
4-bromobenzoic acid hydrazide
Conditions
| Conditions | Yield |
|---|---|
|
4-Bromobenzoic acid;
With
sulfuric acid;
In
ethanol;
for 6h;
Reflux;
With
hydrazine hydrate; sodium hydrogencarbonate; acetic acid;
Reflux;
|
98%
|
|
4-Bromobenzoic acid;
With
1,1'-carbonyldiimidazole;
In
tetrahydrofuran;
With
hydrazine hydrate;
In
tetrahydrofuran;
for 6h;
|
85%
|
|
Multi-step reaction
with
2
steps
1: H2
SO4
2: H2
NNH2
*H2
O
With
sulfuric acid; hydrazine hydrate;
|
|
|
Multi-step reaction
with
2
steps
1: acetic acid anhydride
2: hydrazine hydrate / 0 °C
With
acetic anhydride; hydrazine hydrate;
|
|
|
4-Bromobenzoic acid;
With
N-ethyl-N,N-diisopropylamine; HATU;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.0833333h;
With
hydrazine;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 1h;
|
|
|
Multi-step reaction
with
2
steps
1: thionyl chloride / Microwave irradiation
2: hydrazine hydrate / ethanol / Reflux
With
thionyl chloride; hydrazine hydrate;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: thionyl chloride / 0.07 h / Microwave irradiation
2: hydrazine hydrate / 0.05 h / Microwave irradiation
With
thionyl chloride; hydrazine hydrate;
|
|
|
Multi-step reaction
with
2
steps
1: Reflux; Acidic conditions
2: hydrazine hydrate / Reflux
With
hydrazine hydrate;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / 4 h / Reflux
2: hydrazine hydrate / water / 0.17 h / 50 - 60 °C
With
sulfuric acid; hydrazine hydrate;
In
water;
1: Fischer esterification;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / 4 h / Reflux
2: hydrazine hydrate / water / 0.17 h / 75 °C
With
sulfuric acid; hydrazine hydrate;
In
water;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid
2: hydrazine hydrate / methanol / Reflux
With
sulfuric acid; hydrazine hydrate;
In
methanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / 4 h / 80 °C
2: hydrazine hydrate / 2 h / 80 °C
With
sulfuric acid; hydrazine hydrate;
|
|
|
Multi-step reaction
with
2
steps
1: thionyl chloride / Microwave irradiation
2: hydrazine hydrate / Microwave irradiation; Reflux
With
thionyl chloride; hydrazine hydrate;
|
|
|
Multi-step reaction
with
2
steps
1: Acidic conditions; Reflux
2: hydrazine hydrate / Reflux
With
hydrazine hydrate;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid
2: hydrazine hydrate
With
sulfuric acid; hydrazine hydrate;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / Reflux
2: hydrazine hydrate
With
sulfuric acid; hydrazine hydrate;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / 0.2 h / Reflux; Microwave irradiation
2: hydrazine hydrate / ethanol / 0.23 h / Reflux; Microwave irradiation
With
hydrazine hydrate; sulfuric acid;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / 4 h / Reflux
2: hydrazine hydrate / water / 0.5 h / Reflux
With
sulfuric acid; hydrazine hydrate;
In
water;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / Reflux
2: hydrazine hydrate / methanol / Reflux
With
sulfuric acid; hydrazine hydrate;
In
methanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / Reflux
2: hydrazine hydrate / methanol / Reflux
With
sulfuric acid; hydrazine hydrate;
In
methanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / 20 °C
2: hydrazine hydrate / methanol / Reflux
With
sulfuric acid; hydrazine hydrate;
In
methanol;
|
|
|
Multi-step reaction
with
2
steps
1: hydrogenchloride / Reflux
2: hydrazine hydrate / Reflux
With
hydrogenchloride; hydrazine hydrate;
|
|
|
Multi-step reaction
with
2
steps
1: thionyl chloride / 12.5 h / 0 - 80 °C / Inert atmosphere
2: hydrazine hydrate / methanol / 12 h / 65 °C
With
thionyl chloride; hydrazine hydrate;
In
methanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid
2: hydrazine hydrate / methanol
With
sulfuric acid; hydrazine hydrate;
In
methanol;
|
|
|
Multi-step reaction
with
3
steps
1: thionyl chloride / 5 h / Reflux
2: triethylamine / dichloromethane / 0 °C
3: hydrazine hydrate / methanol / 5 h / Reflux
With
thionyl chloride; hydrazine hydrate; triethylamine;
In
methanol; dichloromethane;
|
|
|
With
hydrazine hydrate;
at 90 ℃;
for 0.5h;
Microwave irradiation;
|
|
|
With
thionyl chloride; hydrazine hydrate;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / 110 °C
2: hydrazine hydrate / ethanol / 12 h / 100 °C
With
hydrazine hydrate; sulfuric acid;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / 6 h / Reflux
2: hydrazine hydrate / methanol / 8 h / Reflux
With
sulfuric acid; hydrazine hydrate;
In
methanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / Reflux
2: hydrazine hydrate / ethanol / Reflux
With
sulfuric acid; hydrazine hydrate;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / Reflux
2: hydrazine hydrate
With
sulfuric acid; hydrazine hydrate;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / 12 h / 70 - 80 °C / Reflux
2: hydrazine hydrate / ethanol / Reflux
With
sulfuric acid; hydrazine hydrate;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: thionyl chloride
2: hydrazine hydrate / ethanol / Reflux
With
thionyl chloride; hydrazine hydrate;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: thionyl chloride / Reflux
2: hydrazine hydrate / ethanol / Reflux
With
thionyl chloride; hydrazine hydrate;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / water / 6 h / Reflux
2: hydrazine hydrate / water; ethanol / Reflux
With
sulfuric acid; hydrazine hydrate;
In
ethanol; water;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid
2: hydrazine hydrate / methanol
With
sulfuric acid; hydrazine hydrate;
In
methanol;
|
|
|
Multi-step reaction
with
2
steps
1: thionyl chloride / Reflux
2: ethanol / Reflux
With
thionyl chloride;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: tetrahydrofuran / 20 °C
2: hydrazine hydrate / tetrahydrofuran / 20 °C
With
hydrazine hydrate;
In
tetrahydrofuran;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / Reflux
2: hydrazine hydrate / ethanol / Reflux
With
hydrazine hydrate; sulfuric acid;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: Acidic conditions
2: hydrazine hydrate / Reflux
With
hydrazine hydrate;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / 3 h / 70 °C
2: H4
N2
*5H2
O / ethanol / 6 h / 70 °C
With
sulfuric acid; H4N2*5H2O;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / 10 h / Reflux
2: hydrazine hydrate / ethanol / 8 h / Reflux
With
sulfuric acid; hydrazine hydrate;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / 8 h / Reflux
2: hydrazine hydrate / ethanol / 6 h / Reflux
With
sulfuric acid; hydrazine hydrate;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: glycerol-based sulfonic acid functionalized carbon catalyst / 6 h / Reflux; Green chemistry
2: hydrazine hydrate / methanol / 8 h / Reflux
With
hydrazine hydrate;
In
methanol;
|
|
|
Multi-step reaction
with
2
steps
1: tetrahydrofuran / 2 h / 20 °C
2: hydrazine hydrate / 20 °C
With
hydrazine hydrate;
In
tetrahydrofuran;
|
|
|
Multi-step reaction
with
2
steps
1.1: 0.17 h / 0 °C
1.2: 6 h / Reflux
2.1: methanol / 0.17 h / 0 °C
2.2: 8 h / Reflux
In
methanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / water / 12 h / Reflux
2: hydrazine hydrate / ethanol / Reflux
With
sulfuric acid; hydrazine hydrate;
In
ethanol; water;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / Reflux
2: hydrazine hydrate / ethanol / 5 h / Reflux
With
sulfuric acid; hydrazine hydrate;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / Reflux
2: hydrazine hydrate / Reflux
With
hydrazine hydrate; sulfuric acid;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / Reflux
2: hydrazine hydrate / Reflux
With
sulfuric acid; hydrazine hydrate;
|
|
|
With
sulfuric acid; hydrazine hydrate;
In
methanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / water / 6 h / 100 °C
2: ethanol; hydrazine / 12 h / Heating / reflux
With
ethanol; sulfuric acid; hydrazine;
In
water;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / Reflux
2: hydrazine hydrate / Cooling with ice; Reflux
With
sulfuric acid; hydrazine hydrate;
|
|
|
With
hydrazine hydrate;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / Reflux
2: hydrazine hydrate / ethanol / Reflux
With
sulfuric acid; hydrazine hydrate;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / Reflux
2: hydrazine hydrate / ethanol / Reflux
With
sulfuric acid; hydrazine hydrate;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: Heating; Acidic conditions
2: hydrazine / ethanol / Heating
With
hydrazine;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / Reflux
2: hydrazine hydrate / Reflux
With
hydrazine hydrate; sulfuric acid;
|
|
|
Multi-step reaction
with
2
steps
1: thionyl chloride / 1 h / 40 °C
2: hydrazine hydrate / methanol / 4 h / 65 °C
With
thionyl chloride; hydrazine hydrate;
In
methanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / 0.1 h / Microwave irradiation
2: hydrazine hydrate / methanol / 0.07 h / Microwave irradiation
With
sulfuric acid; hydrazine hydrate;
In
methanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / 2 h / Reflux
2: hydrazine hydrate / methanol / 0 °C / Reflux
With
sulfuric acid; hydrazine hydrate;
In
methanol;
|
|
|
Multi-step reaction
with
2
steps
1: thionyl chloride / 8 h / 80 °C
2: hydrazine hydrate / ethanol / 80 °C
With
thionyl chloride; hydrazine hydrate;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / 2 h / 78 °C
2: hydrazine hydrate / ethanol / 6 h / 78 °C
With
sulfuric acid; hydrazine hydrate;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / 5 h / 70 - 80 °C
2: hydrazine hydrate / ethanol / 5 h / 80 °C
With
sulfuric acid; hydrazine hydrate;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / 24 h / Reflux
2: hydrazine hydrate / ethanol / Reflux
With
sulfuric acid; hydrazine hydrate;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid
2: hydrazine hydrate / ethanol / 4 h / Reflux
With
sulfuric acid; hydrazine hydrate;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / Reflux
2: hydrazine hydrate / Reflux
With
sulfuric acid; hydrazine hydrate;
|
-
-
586-75-4
4-chlorobenzoyl chloride
-
-
5933-32-4
4-bromobenzoic acid hydrazide
Conditions
| Conditions | Yield |
|---|---|
|
With
hydrazine hydrate;
In
ethanol; dichloromethane;
at 0 - 20 ℃;
Cooling with ice;
|
24%
|
|
Multi-step reaction
with
2
steps
1: aq. NaOH / 0.5 h
2: hydrazine hydrate / methanol / 0.5 h / Heating
With
sodium hydroxide; hydrazine hydrate;
In
methanol;
|
|
|
With
hydrazine;
|
|
|
Multi-step reaction
with
2
steps
1: triethylamine / dichloromethane / 0 °C
2: hydrazine hydrate / methanol / 5 h / Reflux
With
hydrazine hydrate; triethylamine;
In
methanol; dichloromethane;
|
|
|
With
hydrazine hydrate;
In
dichloromethane;
at 0 - 20 ℃;
for 12h;
|
|
|
Multi-step reaction
with
2
steps
1: sodium hydroxide
2: hydrazine hydrate / methanol
With
hydrazine hydrate; sodium hydroxide;
In
methanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid / 5 h / 60 °C
2: hydrazine hydrate / 12 h / 80 °C
With
sulfuric acid; hydrazine hydrate;
|
5933-32-4 Upstream products
-
5798-75-4
Ethyl 4-bromobenzoate
-
1633-33-6
4-bromobenzoic anhydride
-
619-42-1
4-methoxycarbonylphenyl bromide
-
5798-76-5
phenyl 4-bromobenzoate
5933-32-4 Downstream products
-
93444-96-3
furfural-(4-bromo-benzoylhydrazone)
-
74038-71-4
N’-acetyl-4-bromobenzohydrazide
-
76328-73-9
3-(4-bromo-benzoylhydrazono)-butyric acid ethyl ester
-
120124-60-9
4-bromo-benzoic acid-(4-nitro-benzylidenehydrazide)